Loyola University Chicago

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Loyola University Chicago

Department of Chemistry and Biochemistry

Research

Becker, Daniel

Title/s: Associate Professor

Office #: FH-215

Phone: 773.508.3089

E-mail: dbecke3@luc.edu

CV Link: CV 7-2013

Degrees

Research Interests

‌Our research is focused on the design and synthesis of metalloenzyme inhibitors and also of serine protease and serine hydrolase inhibitors with antibiotic properties. In addition, we are interested in the synthesis and conformational dynamics of supramolecular scaffolds related to cyclotriveratrylene (CTV) with applications in host-guest chemistry. Other active research areas involve synthetic methodology including cascade reactions and metal-catalyzed functionalization reactions.

Becker research group

Dr. Andrea Panagopoulos presenting her N3-CTV work.

Magic Hands Marlon Lutz

Selected Publications

Danuta M. Gillner, Daniel P. Becker, and Richard C. Holz, "Lysine Biosynthesis in Bacteria: A Metallodesuccinylase as a Potential Antimicrobial Target", Journal of Biological Inorganic Chemistry (JBIC) 2013, 18(2), 155-163 DOI: 10.1007/s00775-012-0965-1.

Samuel R.S. Sarsah, Marlon R. Lutz Jr., Matthias Zeller, David S. Crumrine, and Daniel P. Becker, “Rearrangement of Cyclotriveratrylene (CTV) Diketone: 9,10-Diarylanthracenes with OLED Applications” J. Org Chem. 2013, 78 2051-2058.DOI: 10.1021/jo302139w.

Andria M. Panagopoulos, Doug Steinman, Alexandra Goncharenko, Kyle Geary,Carlene Schleisman, Elizabeth Spaargaren, Matthias Zeller, and Daniel P. Becker, “Apparent Alkyl Transfer and Phenazine Formation via an Aryne Intermediate”, J. Org. Chem., 2013, 78, 3532−3540, Featured Article, DOI: 10.1021/jo302795w.

Ekaterina I. Filippova, Leigh A. Weston, Misty L. Kuh2, Brett Geisslr3, Alexandra M. Gehrin1, Nicola Armoush, Chinessa T. Adkins, George Minasov, Ievgeniia Dubrovska, Ludmilla Shuvalova, James R. Winsor, Luke D. Lavis, Karla J. F. Satchell, Daniel P. Becker, Wayne F. Anderson, and R. Jeremy Johnson, “Large-scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysis” J. Biol. Chem., 2013, 288(15), 10522-10535, doi:10.1074/jbc.M112.446625.

Marlon R. Lutz Jr., Matthias Zeller, Samuel Sarsah, Artur Filipowicz, Hailey Wouters, and Daniel P. Becker, “Synthesis, Crystal Structure, and Rearrangements of ortho-Cyclophane Cyclotetraveratrylene (CTTV) Tetraketone”, Supramolecular Chemistry, 2012, 24, 803-809. DOI: 10.1080/10610278.2012.719081.

Othman A. Hamed, Arab El-Qisairi, Hanan Qaseer, Emad M. Hamed, Patrick M. Henry, and Daniel P. Becker, Asymmetric a-Hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex”, Tetrahedron Lett., 2012, 53, 10.1016/j.tetlet.2012.03.066.

Osner, Zachary; Nyamjav, Dorjderem; Holz, Richard; Becker, Daniel P. “Direct Patterning of a Cyclotriveratrylene (CTV) Derivative for Directed Self-Assembly of C60“.  Nanotechnology, 2011, 22, 275611.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Easton, Alan M.; Hockerman, Susan L.; Kiefer, James; Munie, Grace E.; Mathis, Karl J.; Li, Madeleine H.; Rico, Joseph G.; Villamil, Clara I.; Williams, Jennifer M. “MMP-13 Selective a-Sulfone Hydroxamates:  A Survey of P1’ Heterocyclic Amide Isosteres”   Bioorganic & Medicinal Chemistry Letters, 2011, 21 2820-2822.

Fobian, Yvette; Freskos, John N.; Barta, Thomas E.; Heintz, Robert; Kiefer, James R.; Mischke, Brent V.; Mullins, Patrick; Munie, Grace E.; Becker, Daniel P. “MMP-13 Selective a-Sulfone Hydroxamates Identification of selective P1’ Amides” Bioorganic & Medicinal Chemistry Letters, 2011, 21 2823-2825.

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell, Terri L. Boehm, Brian R. Bond, Jeffery Carroll, Chris P. Carron, Gary A. DeCrescenzo, Alan M. Easton, John Freskos, Chris L. Funckes-Shippy, Marcia Heron, Susan Hockerman, Susan Carol Howard, James R. Kiefer, Madeleine H. Li, Karl J. Mathis, Joseph J. McDonald, Pramod P. Mehta, Grace E. Munie, Teresa Sunyer, Craig A. Swearingen, Clara I. Villamil, Dean Welsch, Jennifer M. Williams, Jun Yao, Ying Yu “Orally-Active MMP-1 Sparing a-Tetrahydropyranyl and a-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease” Journal of Medicinal Chemistry, 2010 53 6653-6680.  Highlighted in SciBX: Science-Business eXchange September 2, 2010, Volume 3, number 34.

Hamed, Othman; Henry, Patrick; Becker, Daniel P. “Palladium(II)-Catalyzed Dicarboxymethylation of Chiral Allylic Alcohols:  Chirality Transfer Affording  Optically Active Diesters Containing Three Contiguous Chiral Centers“ Tetrahedron Lett., 2010, 51, 3514-3517.

Stephen A. Kolodziej, Susan L. Hockerman, Gary A. DeCrescenzo, Joseph J. McDonald, Debbie A. Mischke, Grace E. Munie, Theresa R. Fletcher, Nathan W. Stehle, Craig Swearingen and Daniel P. Becker “MMP-13 Selective Isonipecotamide alpha-Sulfone Hydroxamates” Bioorganic & Medicinal Chemistry Letters, 2010, 20 3561-3564. 

Stephen A. Kolodziej, Susan L. Hockerman, Terri L. Boehm,, Joseph G. Rico, Jeffery N. Carroll, Gary A. De Crescenzo, Joseph J. McDonald, Debbie A. Mischke, Grace E. Munie, Theresa R. Fletcher, Nathan W. Stehle, Craig Swearingen and Daniel P. Becker, “Orally Bioavailable Dual MMP-1/MMP-14 Sparing MMP-13 Selective alpha-Sulfone Hydroxamates” Bioorganic & Medicinal Chemistry Letters, 2010, 20 3557-3560. 

French, David; Lutz, Marlon R.; Lu, Chichi; Zeller, Matthias; Becker, Daniel P. “A Thermodynamic and Kinetic Characterization of the Solvent Dependence of the Saddle-Crown Equilibrium of Cyclotriveratrylene (CTV) Oxime,  J. Phys. Chem A., 2009, 113, 8258-8267. 

Gillner, Danuta; Nicola Armoush, Holz; Richard C.; and Becker, Daniel P. “Inhibitors of Bacterial N-Succinyl-L,L-diaminopimelic Acid Desuccinylase (DapE) and Demonstration of in vitro Antimicrobial Activity” Bioorganic & Medicinal Chemistry Letters, 2009, 19, 6350-6352.

Zeller, Matthias; Lutz Jr., Marlon R.; Becker, Daniel P. “An aza-cyclophane stacked in racemic columnar assemblies:  Whole molecular disorder in a 2D solid solution“  Acta Cryst B: Structural Science 2009, 65(2), 223-229. PMID: 19299878

Lutz Jr., Marlon R.; Zeller, Matthias; Becker, Daniel P. "Beckmann Rearrangement of Cyclotriveratrylene (CTV) Oxime: Tandem Beckmann-Electrophilic AromaticAddition", Tetrahedron Letters 2008, 49, 5003-5005.

Armoush, Nicola; Kataria, Preeti; Becker, Daniel P. "Synthesis of Substituted 2-Amino-Cyclobutanones", Synthetic Communications 2008, 38 (11), 1679-1687.

Lutz Jr., Marlon R., French, David C., Rehage, Peter, & Becker, Daniel P. "Isolation of the saddle and crown conformers of cyclotriveratrylene (CTV) oxime", Tetrahedron Lett. 2007, 48, 6368-6371.

Loyola

Department of Chemistry & Biochemistry
Loyola University Chicago · 1032 W. Sheridan Rd., Chicago, IL 60660
Phone: 773.508.3100 · Fax: 773.508.3086

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