Title/s: Assistant Professor
Office #: FH-213
External Webpage: http://www.eichmangroup.com/
- 2010-2012 Postdoctoral Fellow, Northwestern University
- 2010 Ph.D. Chemistry, The Ohio State University
- 2005 B.S. Chemistry, University of Wisconsin–Madison
Research in the Eichman group is focused on the development of catalytic processes that enable new reactions for organic synthesis. Expanding on this central theme, we are interested in two main areas: 1) new catalyst design for biomimetic transformations, and 2) incorporating renewable resources into complex molecule synthesis. Nature’s approach toward the synthesis of complex molecules typically involves rapid generation of advanced intermediates from relatively simple building blocks. Adopting a similar approach in a chemical synthesis laboratory is challenging and often requires the integration of novel bond construction techniques. Introducing high levels of molecular complexity in a single synthetic operation alleviates the need for long, linear synthetic sequences. Toward this goal, our primary objective is to design transition metal and metal-free catalysts for new reaction discovery. These reactions will be employed in constructing biologically active scaffolds, the testing of which will lead to collaborative chemical biology studies. Concurrently, mechanistic investigations of these processes will help increase catalyst efficiency and will ultimately fuel new catalyst discovery.
- American Cancer Society Postdoctoral Fellowship 2012-2015 (declined)
- John S. Swenton Award for Outstanding Teaching by a Graduate Student, 2010
Johnston, R. C.; Cohen, D. T.; Eichman, C. C.; Scheidt, K. A.; Cheong, P. H.-Y. “Catalytic kinetic resolution of a dynamic racemate: highly stereoselective β-lactone formation by N-heterocyclic carbene catalysis” Chem. Sci., 2014, 5, 1974-1982.
Cohen, D. T.; Eichman, C. C.; Phillips, E. M.; Zarefsky, E. R.; Scheidt, K. A. “Catalytic Dynamic Kinetic Resolutions with N-Heterocyclic Carbenes: Asymmetric Synthesis of Highly Substituted β-Lactones”Angew. Chem., Int. Ed. 2012, 51, 7309.
Kunchithapatham, K.; Eichman, C. C.; Stambuli, J. P. “Synthesis of Diaryl Ketones via a Phosphine-free Fukuyama Reaction” Chem. Commun. 2011, 47, 12679.
Henderson, W. H.; Alvarez, J. M.; Eichman, C. C.; Stambuli, J. P. “Characterization, Reactivity, and Potential Catalytic Intermediacy of a Cyclometalated Tri-tert-butylphosphine Palladium Acetate Complex” Organometallics, 2011, 30, 5038.
Eichman, C. C.; Bragdon, J. P.; Stambuli, J. P. “Exploiting Guanidine as a Ligand in Cobalt-catalyzed Alkyne Cyclotrimerizations” Synlett 2011, 8, 1109.
Eichman, C. C.; Stambuli, J. P. “Transition Metal Catalyzed Synthesis of Aryl Sulfides” Molecules Invited Contribution for Special Homogenous Catalysis Issue 2011, 16, 590.
Counceller, C. M.; Eichman, C. C.; Stambuli, J. P. “Synthesis of 2,4- and 2,5-Disubstituted Oxazoles via Metal-Catalyzed Cross-Coupling Reactions” Adv. Synth. Catal. 2011, 353, 79.
Counceller, C. M.; Eichman, C. C.; Wray, B. C.; Welin, E. R.; Stambuli, J. P. “Synthesis of 3-methyl-1H-Indazole via Metal-Free Electrophilic Amination” Org. Synth. 2011, 88, 33.
Eichman, C. C.; Stambuli, J. P. “Zinc-Mediated Palladium-Catalyzed Formation of Carbon-Sulfur Bonds” J. Org. Chem. 2009, 74, 4005.
Counceller, C. M.; Eichman, C. C.; Wray, B. C.; Stambuli, J. P. “A Practical, Metal-Free Synthesis of 1H-Indazoles” Org. Lett. 2008, 10, 1021.