Protein Kinase Cascade
A Kinase Cascade is activated when full-grown Xenopus laevis oocytes are stimulated with progesterone. Below is a simplified diagram showing the pathway linking the different kinases. Dashed lines indicate putative feedback loops.
Microinjection of c-mos kinase or raf-1 kinase into oocytes, in the absence of progesterone, will lead to an increase in oocyte pHi. Oocyte pHi