S. Duke Han
	Title:	Assistant Professor, Clinical Psychology
	Office:	Damen Hall 611
	Phone:	773.508.3073
	E-mail:	dhan2@luc.edu

Personal Information

Ph.D., University of Massachusetts Boston
M.A., University of Massachusetts Boston
Neuroscience Certificate, Duke University
B.S., Duke University

Research Interests:
My broad research interests are in neuropsychology and cognitive neuroscience.  I am particularly interested in the neural substrates of successful adaptation.  Current projects in development are directed at elucidating what brain structures and functions are important for (1) adapting to a new and complex environment, (2) coping with stressful situations, and (3) compensating for declines in cognition.  We employ neuropsychological assessment techniques, computer-based neurocognitive paradigms, diverse research populations, and when possible, functional and structural neuroimaging methods to explore these questions.

For example, research has suggested that non-demented elderly participants genetically at greater risk for developing Alzheimer's disease may show a pattern of greater activation in select brain regions than those not at greater risk, despite equivalent behavioral performances between groups on the same associative memory task. The elucidation of this apparent "compensatory mechanism" is one focus of current efforts in the laboratory along with collaborators from the University of California San Diego.

Other interests include the lexical-semantic associative memory disturbance of speech in schizophrenia, the importance of considering executive functioning development in school-age children, and traumatic brain injury (TBI) outcomes among active military personnel. I welcome any students with an interest in clinical neuropsychology or cognitive neuroscience, and I strongly encourage my students to publish and present their research.  For more information please visit our lab web page.

Recent Publications:

Han, S.D., Drake, A.I., Cessante, L.M., Jak, A.J., Houston, W.S., Delis, D.C., Huynh, D.V., Filoteo, J.V., & Bondi, M.W. (in press).  APOE and Recovery from TBI in a U.S. Military Population: Evidence for a Compensatory Mechanism?  Journal of Neurology, Neurosurgery, and Psychiatry.

Han, S.D., Nestor, P.G., Hale-Spencer, M., Cohen, A., Niznikiewicz, M., McCarley, R.W., & Wible, C.G. (2007). Functioning imaging of word priming in males with chronic schizophrenia, Neuroimage, 35, 273-282.

Han, S.D., Houston, W.S., Jak, A.J., Eyler, L.T., Nagel, B.J., Fleisher, A.S., Brown, G.G., Corey-Bloom, J., Salmon, D.P., Thal, L.J., & Bondi, M.W. (2007). Verbal paired-associate learning by APOE genotype in non-demented adults: fMRI evidence of a right hemispheric compensatory response. Neurobiology of Aging, 28, 238-247.

Delis, D.C., Lansing, A., Houston, W.S., Wetter, S., Han, S.D., & Jacobsen, M., Holdnack, J., & Kramer, J. (2007). Creativity lost: The importance of testing higher-level executive functions in school-aged children. The Journal of Psychoeducational Assessment, 25, 29-40.

Wible, C.G., Han, S.D., Spencer, M.H., Kubicki, M., Niznikiewicz, M.H., Jolesz, F.A., McCarley, R.W., & Nestor, P.G. (2006). Connectivity among semantic associates: An fMRI study of semantic priming. Brain and Language, 97, 294-305.

Han, S.D., Nestor, P.G., & Wible, C.G. (2006). fMRI of lexical-semantic priming in a chronic schizophrenia patient. Applied Neuropsychology, 13(1), 51-57.

Scarmeas, N., Stern, Y., Bondi, M.W., & Han, S.D. (2005). fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease. Neurology, 65, 1514-1515.

Han, S.D., Nestor, P.G., Shenton, M.E., Niznikiewicz, M., Hannah, G., & McCarley, R. (2003). Associative memory in chronic schizophrenia: A computational model. Schizophrenia Research, 61, 255-263.

Nestor, P.G., Han, S.D., Niznikiewicz, M., Salisbury, D., Spencer, K., Shenton, M.E., & McCarley, R.W. (2001). Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention. Biological Psychology, 57, 23-46.