Affiliate Associate Professor

Pulmonary and Critical Care Medicine

Parkinson ,Health Informatics and Data Science

Majid Afshar
  • Dr. Afshar is a physician-scientist that helps take care of critically ill patients and patients with substance misuse and severe infections. In addition to seeing patients, Dr. Afshar also performs research using advanced computational methods to build tools to improve and augment clinical decision making at the bedside.

    • Rush Medical College of Rush University, M.D.                
    • Rush University, Masters             
    • University of Illinois at Champaign-Urbana, Bachelors           
    • Medical School: Rush Medical College of Rush University
    • Residency: Rush University Medical Center, Internal Medicine
    • Fellowship: University of Maryland/VAMC Baltimore, Pulmonary and Critical Care Medicine

    What prompted you to pursue your field?

    I have been fortunate to wear two hats as a physician-scientist. I practice medicine to apply quantitative decision making skils with individual patients and their families to improve health, and I apply quanitative methods across data from many patients to help advance the science of healthcare and improving health outcomes. My data science laboratory uses clinical informatics and data science to prevent and quickly identify of diseases in critically ill patients with a focus on substance misuse. My lab employs methods in natural language processing (NLP) and machine learning with a multi-disciplinary team science approach using data from the electronic health record.

    What "called" you to/attracted you to Loyola?

    I found Parkinson's to be the right home where I can wear both hats and contribute to medical research. Loyola is a collaborative health system in the region and has such a large community across campuses and departments.


    • The Effect of Hospital Discharge with Empiric Noninvasive Ventilation on Mortality in Hospitalized Patients with Obesity Hypoventilation Syndrome: An Individual Patient Data Meta-Analysis. Mokhlesi, B; Masa, JF; Afshar, M; Almadana Pacheco, V; Berlowitz, DJ; Borel, JC; Budweiser, S; Carrillo, A; Castro-Añón, O; Ferrer, M; Gagnadoux, F; Golpe, R; Hart, N; Howard, ME; Murphy, PB; Palm, A; Perez de Llano, LA; Piper, AJ; Pépin, JL; Priou, P; Sánchez-Gómez, JF; Soghier, I; Tamae Kakazu, M; Wilson, KC Annals of the American Thoracic Society 2020
    • Weight Loss Interventions as Treatment of Obesity Hypoventilation Syndrome: A Systematic Review. Tamae Kakazu, M; Soghier, I; Afshar, M; Brozek, JL; Wilson, KC; Masa, JF; Mokhlesi, B Annals of the American Thoracic Society 2020
    • The authors reply. Afshar, M; Markossian, T; Joyce, C Critical care medicine 2020 ;48(2)
    • Comparison of Early Warning Scoring Systems for Hospitalized Patients With and Without Infection at Risk for In-Hospital Mortality and Transfer to the Intensive Care Unit. Liu, VX; Lu, Y; Carey, KA; Gilbert, ER; Afshar, M; Akel, M; Shah, NS; Dolan, J; Winslow, C; Kipnis, P; Edelson, DP; Escobar, GJ; Churpek, MM JAMA network open 2020 ;3(5)
    • Summary of the 2019 Alcohol and Immunology Research Interest Group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury. McMahan, RH; Afshar, M; Amedee, AM; Bishehsari, F; Carr, RM; Coleman, LG; Herrnreiter, CJ; Lewis, SL; Mandrekar, P; McCullough, RL; Morris, NL; Vasiliou, V; Wang, HJ; Yeligar, SM; Choudhry, MA; Kovacs, EJ Alcohol (Fayetteville, N.Y.) 2020
    • Publicly available machine learning models for identifying opioid misuse from the clinical notes of hospitalized patients. Sharma, B; Dligach, D; Swope, K; Salisbury-Afshar, E; Karnik, NS; Joyce, C; Afshar, M BMC MEDICAL INFORMATICS AND DECISION MAKING 2020 ;20(1)
    • Validation of an Alcohol Misuse Classifier in Hospitalized Patients. To, D; Sharma, B; Karnik, N; Joyce, C; Dligach, D; Afshar, M Alcohol (Fayetteville, N.Y.) 2019
    • Development and application of a high throughput natural language processing architecture to convert all clinical documents in a clinical data warehouse into standardized medical vocabularies. Afshar, M; Dligach, D; Sharma, B; Cai, X; Boyda, J; Birch, S; Valdez, D; Zelisko, S; Joyce, C; Modave, F; Price, R Journal of the American Medical Informatics Association : JAMIA 2019
    • Evaluation and Management of Obesity Hypoventilation Syndrome. An Official American Thoracic Society Clinical Practice Guideline. Mokhlesi, B; Masa, JF; Brozek, JL; Gurubhagavatula, I; Murphy, PB; Piper, AJ; Tulaimat, A; Afshar, M; Balachandran, JS; Dweik, RA; Grunstein, RR; Hart, N; Kaw, R; Lorenzi-Filho, G; Pamidi, S; Patel, BK; Patil, SP; Pépin, JL; Soghier, I; Tamae Kakazu, M; Teodorescu, M AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2019 ;200(3)
    • Noninvasive Ventilation versus CPAP as Initial Treatment of Obesity Hypoventilation Syndrome: A Systematic Review. Soghier, I; Brozek, JL; Afshar, M; Tamae Kakazu, M; Wilson, KC; Masa, JF; Mokhlesi, B Annals of the American Thoracic Society 2019
    • Subtypes in patients with opioid misuse: A prognostic enrichment strategy using electronic health record data in hospitalized patients. Afshar, M; Joyce, C; Dligach, D; Sharma, B; Kania, R; Xie, M; Swope, K; Salisbury-Afshar, E; Karnik, NS PLoS ONE 2019 ;14(7)
    • Patient Outcomes and Cost-Effectiveness of a Sepsis Care Quality Improvement Program in a Health System. Afshar, M; Arain, E; Ye, C; Gilbert, E; Xie, M; Lee, J; Churpek, MM; Durazo-Arvizu, R; Markossian, T; Joyce, C Critical care medicine 2019
    • Self-reported alcohol use in the cystic fibrosis community. Lowery, EM; Afshar, M; West, N; Kovacs, EJ; Smith, B; Joyce, C Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2019
    • Toward a clinical text encoder: pretraining for clinical natural language processing with applications to substance misuse. Dligach, D; Afshar, M; Miller, T Journal of the American Medical Informatics Association : JAMIA 2019
    • Physician agreement on the diagnosis of sepsis in the intensive care unit: estimation of concordance and analysis of underlying factors in a multicenter cohort. Lopansri, BK; Miller Iii, RR; Burke, JP; Levy, M; Opal, S; Rothman, RE; D'Alessio, FR; Sidhaye, VK; Balk, R; Greenberg, JA; Yoder, M; Patel, GP; Gilbert, E; Afshar, M; Parada, JP; Martin, GS; Esper, AM; Kempker, JA; Narasimhan, M; Tsegaye, A; Hahn, S; Mayo, P; McHugh, L; Rapisarda, A; Sampson, D; Brandon, RA; Seldon, TA; Yager, TD; Brandon, RB Journal of intensive care 2019 ;7
    • Natural language processing and machine learning to identify alcohol misuse from the electronic health record in trauma patients: development and internal validation. Afshar, M; Phillips, A; Karnik, N; Mueller, J; To, D; Gonzalez, R; Price, R; Cooper, R; Joyce, C; Dligach, D Journal of the American Medical Informatics Association : JAMIA 2019 ;26(3)
    • Risk factors for infection and evaluation of Sepsis-3 in patients with trauma. Eguia, E; Cobb, AN; Baker, MS; Joyce, C; Gilbert, E; Gonzalez, R; Afshar, M; Churpek, MM American Journal of Surgery 2019
    • Dietary Patterns, Asthma, and Lung Function in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Han, YY; Jerschow, E; Forno, E; Hua, S; Mossavar-Rahmani, Y; Perreira, K; Sotres-Alvarez, D; Afshar, M; Punjabi, NM; Thyagarajan, B; Shivappa, N; Hébert, JR; Kaplan, RC; Celedón, JC Annals of the American Thoracic Society 2019
    • Outcomes in Burn-Injured Patients Who Develop Sepsis. Rech, MA; Mosier, MJ; McConkey, K; Zelisko, S; Netzer, G; Kovacs, EJ; Afshar, M Journal of burn care & research : official publication of the American Burn Association 2019
    • Identifying Novel Sepsis Subphenotypes Using Temperature Trajectories. Bhavani, SV; Carey, KA; Gilbert, ER; Afshar, M; Verhoef, PA; Churpek, MM AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2019
    • The Role of Positive Airway Pressure Therapy in Adults with Obesity Hypoventilation Syndrome: A Systematic Review and Meta-Analysis. Afshar, M; Brozek, JL; Soghier, I; Tamae Kakazu, M; Wilson, KC; Masa, JF; Mokhlesi, B Annals of the American Thoracic Society 2019
    • Risk Factors and Outcomes of Acute Respiratory Distress Syndrome in Critically Ill Patients with Cirrhosis. Yang, P; Formanek, P; Scaglione, S; Afshar, M Hepatology research : the official journal of the Japan Society of Hepatology 2018
    • Optimal Cut-Points for Phosphatidylethanol Vary by Clinical Setting: Response to Nguyen and Seth's (2018) Letter to the Editor. Afshar, M; Burnham, EL; Joyce, C; Kovacs, EJ; Lowery, EM Alcoholism, Clinical and Experimental Research 2018
    • Impact of the Affordable Care Act (ACA) Medicaid Expansion on Cancer Admissions and Surgeries. Eguia, E; Cobb, AN; Kothari, AN; Molefe, A; Afshar, M; Aranha, GV; Kuo, PC Annals of Surgery 2018
    • Effects of binge alcohol consumption on sleep and inflammation in healthy volunteers. Wilkinson, AN; Afshar, M; Ali, O; Bhatti, W; Hasday, JD; Netzer, G; Verceles, AC The Journal of international medical research 2018
    • Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury: Development and Internal Validation. Afshar, M; Burnham, EL; Joyce, C; Gagnon, R; Dunn, R; Albright, JM; Ramirez, L; Repine, JE; Netzer, G; Kovacs, EJ Annals of Surgery 2018
    • Helping Patients With ESRD and Earlier Stages of CKD to Quit Smoking. Formanek, P; Salisbury-Afshar, E; Afshar, M American Journal of Kidney Diseases : The Official Journal of the National Kidney Foundation 2018 ;72(2)
    • Summary of the 2017 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Hulsebus, HJ; Curtis, BJ; Molina, PE; Afshar, M; Boule, LA; Morris, N; Keshavarzian, A; Kolls, JK; Yeligar, SM; Price, ME; Wyatt, TA; Choudhry, MA; Kovacs, EJ Alcohol (Fayetteville, N.Y.) 2018 ;69
    • Use of alcohol biomarkers to identify alcohol misuse in organ donors. Lowery, EM; Walsh, M; Yong, M; Kovacs, EJ; Joyce, C; Afshar, M Alcohol (Fayetteville, N.Y.) 2018 ;73
    • Validation of a Host Response Assay, Septicyte LAB, for Discriminating Sepsis from SIRS in the ICU Miller Iii,R. R.; Lopansri,B. K.; Burke,J. P.; Levy,M.; Opal,S.; Rothman,R. E.; D'Alessio,F. R.; Sidhaye,V. K.; Aggarwal,N. R.; Balk,R.; Greenberg,J. A.; Yoder,M.; Patel,G.; Gilbert,E.; Afshar,M.; Parada,J. P.; Martin,G. S.; Esper,A. M.; Kempker,J. A.; Narasimhan,M.; Tsegaye,A.; Hahn,S.; Mayo,P.; van der Poll,T.; Schultz,M. J.; Scicluna,B. P.; Klein Klouwenberg,P.; Rapisarda,A.; Seldon,T. A.; McHugh,L. C.; Yager,T. D.; Cermelli,S.; Sampson,D.; Rothwell,V.; Newman,R.; Bhide,S.; Kirk,J. T.; Navalkar,K.; Davis,R. F.; Brandon,R. A.; Brandon,R. B. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2018
    • Racial and Ethnic Postoperative Outcomes After Surgery: The Hispanic Paradox. Eguia, E; Cobb, AN; Kirshenbaum, EJ; Afshar, M; Kuo, PC The Journal of surgical research 2018 ;232
    • A Computable Phenotype for Acute Respiratory Distress Syndrome Using Natural Language Processing and Machine Learning. Afshar, M; Joyce, C; Oakey, A; Formanek, P; Yang, P; Churpek, MM; Cooper, RS; Zelisko, S; Price, R; Dligach, D AMIA ... Annual Symposium proceedings. AMIA Symposium 2018 ;2018
    • Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes Frankel,J. H.; Boe,D. M.; Albright,J. M.; O'Halloran,E. B.; Carter,S. R.; Davis,C. S.; Ramirez,L.; Burnham,E. L.; Gamelli,R. L.; Afshar,M.; Kovacs,E. J. Experimental gerontology 2018 ;105:78-86
    • Letter to the Editor: Ding Q, Wang Z, Shen M, Su Z, and Shen L (2017) Acute Alcohol Exposure and Risk of Mortality of Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis Afshar,M.; Albrecht,J. S. Alcoholism, Clinical and Experimental Research 2017 ;41(12):2217-2218
    • Cut-Point Levels of Phosphatidylethanol to Identify Alcohol Misuse in a Mixed Cohort Including Critically Ill Patients Afshar,M.; Burnham,E. L.; Joyce,C.; Clark,B. J.; Yong,M.; Gaydos,J.; Cooper,R. S.; Smith,G. S.; Kovacs,E. J.; Lowery,E. M. Alcoholism, Clinical and Experimental Research 2017 ;41(10):1745-1753
    • The Contributing Risk of Tobacco Use for ARDS Development in Burn-Injured Adults With Inhalation Injury Afshar,M.; Netzer,G.; Mosier,M. J.; Cooper,R. S.; Adams,W.; Burnham,E. L.; Kovacs,E. J.; Durazo-Arvizu,R.; Kliethermes,S. Respiratory care 2017 ;62(11):1456-1465
    • A computable phenotype for asthma case identification in adult and pediatric patients: External validation in the Chicago Area Patient-Outcomes Research Network (CAPriCORN) Afshar,M.; Press,V. G.; Robison,R. G.; Kho,A. N.; Bandi,S.; Biswas,A.; Avila,P. C.; Kumar,H. V. M.; Yu,B.; Naureckas,E. T.; Nyenhuis,S. M.; Codispoti,C. D. The Journal of asthma : official journal of the Association for the Care of Asthma 2017 :1-8
    • Association of Serum Lipids and Obstructive Lung Disease in Hispanic/Latino Adults of Diverse Backgrounds Afshar,M.; Wu,D.; Durazo-Arvizu,R.; Aguilar,F. G.; Kalhan,R.; Davis,S. M.; Kaplan,R.; Klein,O. L.; Mende,E. P.; Pattany,M. S.; Daviglus,M. L. Journal of pulmonary & respiratory medicine 2017 ;7(4):10.4172/2161-105X.1000419. Epub 2017 Aug 31
    • Alcohol is Not Protective against Mortality Following Traumatic Brain Injury Albrecht,J. S.; Afshar,M.; Stein,D. M.; Smith,G. S. American Journal of Epidemiology 2017
    • Family Presence at First Cardiopulmonary Resuscitation and Subsequent Limitations on Care in the Medical Intensive Care Unit Krochmal,R. L.; Blenko,J. W.; Afshar,M.; Netzer,G.; Roy,S. C.; Wiegand,D. L.; Shanholtz,C. B. American Journal of Critical Care : An Official Publication, American Association of Critical-Care Nurses 2017 ;26(3):221-228
    • Comparison of Automated Methods Versus the American Burn Association Sepsis Definition to Identify Sepsis and Sepsis With Organ Dysfunction/Septic Shock in Burn-Injured Adults Rech,M. A.; Mosier,M. J.; Zelisko,S.; Netzer,G.; Kovacs,E. J.; Afshar,M. Journal of burn care & research : official publication of the American Burn Association 2017
    • Ten-year Single Center Experience of Pulmonary Carcinoid Tumors and Diagnostic Yield of Bronchoscopic Biopsy Dixon,R. K.; Britt,E. J.; Netzer,G. A.; Afshar,M.; Burke,A.; Liu,S.; Jean,J.; Shah,N. G. LUNG 2016 ;194(6):905-910
    • Azithromycin use and outcomes in severe sepsis patients with and without pneumonia Afshar,M.; Foster,C. L.; Layden,J. E.; Burnham,E. L. Journal of critical care 2016 ;32:120-125
    • Advanced Age Alters Monocyte and Macrophage Responses Albright,J. M.; Dunn,R. C.; Shults,J. A.; Boe,D. M.; Afshar,M.; Kovacs,E. Antioxidants & redox signaling 2016
    • Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders O'Halloran,E. B.; Curtis,B. J.; Afshar,M.; Chen,M. M.; Kovacs,E. J.; Burnham,E. L. Alcohol (Fayetteville, N.Y.) 2016 ;50:43-50
    • Exhaled nitric oxide levels among adults with excessive alcohol consumption Afshar,M.; Poole,J. A.; Cao,G.; Durazo,R.; Cooper,R. C.; Kovacs,E. J.; Sisson,J. H. Chest 2016
    • Trauma indices for prediction of acute respiratory distress syndrome Afshar,M.; Smith,G. S.; Cooper,R. S.; Murthi,S.; Netzer,G. The Journal of surgical research 2016 ;201(2):394-401
    • Acute respiratory distress syndrome and outcomes after near hanging Mansoor,S.; Afshar,M.; Barrett,M.; Smith,G. S.; Barr,E. A.; Lissauer,M. E.; McCurdy,M. T.; Murthi,S. B.; Netzer,G. The American Journal of Emergency Medicine 2015 ;33(3):359-362
    • Acute immunomodulatory effects of binge alcohol ingestion Afshar,M.; Richards,S.; Mann,D.; Cross,A.; Smith,G. B.; Netzer,G.; Kovacs,E.; Hasday,J. Alcohol (Fayetteville, N.Y.) 2015 ;49(1):57-64
    • Alcohol exposure, injury, and death in trauma patients Afshar,M.; Netzer,G.; Murthi,S.; Smith,G. S. The journal of trauma and acute care surgery 2015 ;79(4):643-648
    • Injured patients with very high blood alcohol concentrations Afshar,M.; Netzer,G.; Salisbury-Afshar,E.; Murthi,S.; Smith,G. S. Injury 2015
    • Half of the family members of critically ill patients experience excessive daytime sleepiness Verceles,A. C.; Corwin,D. S.; Afshar,M.; Friedman,E. B.; McCurdy,M. T.; Shanholtz,C.; Oakjones,K.; Zubrow,M. T.; Titus,J.; Netzer,G. Intensive care medicine 2014 ;40(8):1124-1131
    • The international epidemiology of acute respiratory distress syndrome: how can we think locally and measure globally?* Afshar,M.; Netzer,G. Critical care medicine 2014 ;42(3):739-740
    • Blood alcohol content, injury severity, and adult respiratory distress syndrome Afshar,M.; Smith,G. S.; Terrin,M. L.; Barrett,M.; Lissauer,M. E.; Mansoor,S.; Jeudy,J.; Netzer,G. The journal of trauma and acute care surgery 2014 ;76(6):1447-1455
    • Update in critical care for the nephrologist: transfusion in nonhemorrhaging critically ill patients Afshar,M.; Netzer,G. Advances in Chronic Kidney Disease 2013 ;20(1):30-38
    • Pulmonary hypertension in elderly patients with diastolic dysfunction and preserved ejection fraction Afshar,M.; Collado,F.; Doukky,R. The open cardiovascular medicine journal 2012 ;6:1-8
    • Nonpharmacologic approach to minimizing shivering during surface cooling: a proof of principle study Shah,N. G.; Cowan,M. J.; Pickering,E.; Sareh,H.; Afshar,M.; Fox,D.; Marron,J.; Davis,J.; Herold,K.; Shanholtz,C. B.; Hasday,J. D. Journal of critical care 2012 ;27(6):746.e1-746.e8
    • Narrative review: tetanus-a health threat after natural disasters in developing countries Afshar,M.; Raju,M.; Ansell,D.; Bleck,T. P. Annals of Internal Medicine 2011 ;154(5):329-335
    • A 74-year-old man with an enlarging pleural-based mass that was not a mesothelioma Afshar,M.; Kim,A. W.; Liptay,M. J.; Leyenson,V.; Wirtz,W.; Kahan,E.; Ries,M. The Thoracic and cardiovascular surgeon 2009 ;57(4):244-246