Health Sciences Research
Kuo lab kidney research looks to aid in heart failure treatments
Our kidneys, the pair of organs charged with filtering our blood and controlling our body’s fluid levels, are normally the size of small oranges. But for someone with autosomal dominant polycystic kidney disease (ADPKD), their kidneys can grow to be the size of a football and weigh 30 pounds each.
ADPKD is a rare genetic disorder that causes cysts to grow in the kidneys, and eventually causes kidney failure. But as Loyola University Chicago researcher Ivana Kuo, PhD, has found, how ADPKD is also contributing to heart disease could be key in treating a common cardiac condition: congestive heart failure.
“This has been intriguing for me as a basic science researcher, because it shifted my focus from a very specific genetic disorder to something that might have larger ramifications for millions of people with heart disease as well."
Kuo’s work is in partnership with Arlene Chapman, MD, a University of Chicago clinical nephrologist who studies high blood pressure, kidney disease, and cardiac complications in ADPKD.