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Department of Ophthalmology
Stritch School of Medicine
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Bruce I Gaynes, OD, PharmD

Associate Professor of Ophthalmology

Education

  • B.S., Visual Science – Illinois College of Optometry, Chicago, IL
  • O.D., Doctor of Optometry – Illinois College of Optometry, Chicago, IL
  • Residency, Optometry – Department of Veterans Affairs Medical Center, Newington, CT
  • M.S., Pharmacology – Indiana University Medical Science Program, Bloomington, IN
  • Pharm.D., Pharmacy – University of Illinois College of Pharmacy, Chicago, IL
  • Geriatric Medicine Traineeship – University of Pennsylvania School of Medicine, Delaware Valley Geriatric Education Training Center, Philadelphia, PA

Research Interests

Research Focus: Ocular Pharmacology, Clinical Trials, Aging and Vision, Veterans Health

Summary of Research Interests
Dr. Gaynes' research focuses on ocular pharmacology, aging-related ocular disease, and clinical outcomes in veteran populations. He is actively involved in clinical research aimed at improving pharmacotherapeutic interventions for ocular conditions such as glaucoma, dry eye disease, and infectious keratitis. His interests also include optimizing interdisciplinary care models between optometry, pharmacy, and ophthalmology to enhance treatment adherence and health outcomes in older adults. Through his dual expertise in optometry and pharmacology, he investigates drug delivery systems and the impact of systemic medications on ocular health. Dr. Gaynes contributes to the field through journal peer review and editorial work and is currently an associate editor for BMC Ophthalmology.

Publications/Research Listings

2025

  • Ramini A, Zaffer A, Cortes MC, Ramic A, Patel R, Gaynes B. Pupillary Response Patterns in Patients with Known Substance Use Based on Stimulus Chromaticity; A Pedagogically Based Assessment. Curr Eye Res. 2025 Oct 27:1-8. doi: 10.1080/02713683.2025.2577767. Epub ahead of print. PMID: 41143850.

2024

  • Hakim R, Li M, Gorbien M, Gaynes BI. Real-World Performance Benchmarks in the Reading Ability of Prescription Drug Labels by Community-Dwelling Older Adults. Journal of Pharmacy Practice. 2024;0(0). doi:10.1177/08971900241248503.
  • Li M, Gende M, Tovar A, Schmeling M, Tidow-Kebritchi S, Gaynes BI. Assessing chronic heavy metal exposure by analysis of human cataract specimens and the relationship to metabolic profiles. Curr Eye Res. 2024 Dec 9. doi:10.1080/02713683.2024.2421932.

2022

  • Patel N, Duong S, Mirbod P, Xu J. Gaynes BI. A meta-analysis of variability in conjunctival microvascular hemorheology metrics. Microvascular Research. 2022 February; 142:104340. doi:10.1016/j.mvr.2022.104340. PMID: 35151720.
  • Gaynes BI, Shapiro MD, Augustine AS, Xu Y, Lin Y, Mirbod P, Dieter RS, Cheng Y, Wu M, Venkataraman H, Gao Y, Petrov P, Xu J. Hierarchical data visualization of experimental erythrocyte aggregation employing cross correlation and optical flow applications. Microvascular Research. 2022 May;143:104386. doi:10.1016/j.mvr.2022.104386. Epub ahead of print. PMID: 35623407.
  • Gaynes BI, ACCP Public Policy Committee. Over-the-Counter Epinephrine for Asthma Treatment: Too Much Risk for Too Little Benefit. Journal of Clinical Pharmacology. 2022 September. 0(0):1–3. doi:10.1002/jcph.2146. Epub ahead of print. PMID: 36057794.
  • Hakim R, Patel N, Veryovkin I, Gaynes BI. Effect of Age and Viscosity on Duration of Corneal Anesthesia with Topical 2% Lidocaine Administration. J Ocul Pharmacol Ther. 2022 Dec;38(10):709-716. doi:10.1089/jop.2022.0076. Epub 2022 Nov 14. PMID: 36374966.

2021

  • Tabashum T, Zaffer A, Yousefzai R, Colletta K, Jost MB, Park Y, Chawla J, Albert MV, Gaynes BI, Xiao T. Detection of Parkinson's Disease through Automated Pupil Tracking of the Post-illumination Pupillary Response. Frontiers in Medicine. 2021 March; 8:316. PMID: 33842509. PMCID: PMC8026862.
  • Pai SM, Othman AA, Rusch L, Masters JC, Greene D, Rogge M, Gries JM, Clementi W, Kumar P, Younis I, Salem AH, Gaynes BI, Pastino G, Derendorf H, Public Policy Committee of the American College of Clinical Pharmacology. Science and Evidence-Based Review and Approval of COVID-19 Vaccines: A Statement of Support for the US FDA. Journal of Clinical Pharmacology. 2021 March. 61(3):277-279. doi:10.1002/jcph.1794. PMID:33274473. PMCID:PMC7754558.
  • Gaynes BI, Zaffer A, Yousefzai R, Chazaro-Cortes M, Colletta K, Kletzel SL, Jost MB, Park Y, Chawla J, Albert MV, Xiao T. Variable abnormality of the melanopsin-derived portion of the pupillary light reflex (PLR) in patients with Parkinson's disease (PD) and parkinsonism features. Neurological Sciences. 2021 May; doi:10.1007/s10072-021-05245-8. Epub ahead of print. PMID:33945034.
  • Gao Y, Wu M, Gaynes BI, Dieter RS, Xu J. Study of ultrasound thrombolysis using acoustic bubbles in a microfluidic device. Lab Chip. 2021 August; doi:10.1039/d1lc00276g. PMID: 34350927.
  • Brahmbhatt P, Khanna S, William A, Gaynes, BI, Bouchard CS. Lipid Layer Thickness, Blink Parameters, and Meiboscore in Patients with Dry Eye Disease: ARetrospective Cohort Study. ARVO abstract#3546770, ARVO Annual Meeting, Virtual, 2021.

2020

  • Pai SM, Othman AA, Rusch L, Masters JC, Greene D, Rogge M, Gries JM, Clementi W, Kumar P, Younis I, Salem AH, Gaynes BI, Pastino G, Derendorf H. Science and Evidence-based Review and Approval of COVID-19 Vaccines: A Statement of Support for the U.S. FDA. Journal of Clinical Pharmacology. 2020 December; 61(3):277-279.

2019

  • Thompson JM, Truong AH, Stern HD, Djalilian A, Cortina MS, Tu EY, Johnson P, Verdier DD, Rafo L, Lubeck D, Spektor T, Jorgensen C, Rubenstein JB, Majmudar PA, Talati R, Basti S, Feder R, Sugar A, Mian SI, Balasubramanian N, Sandhu J, Gaynes BI, Bouchard CS. A Multicenter Study Evaluating the Risk Factors and Outcomes of Repeat Descemet Stripping Endothelial Keratoplasty. Cornea. 2019 February; 38(2):177-182. doi:10.1097/ICO.0000000000001817. PMID:30615600.
  • Salinger CL, Gaynes BI, Rajpal RK. Innovations in Topical Ocular Corticosteroid Therapy for the Management of Postoperative Ocular Inflammation and Pain. American Journal of Medical Care. 2019 July; 25:S215-S226. PMID:31419092.
  • Andino D, Moy J, Gaynes BI. Serum vitamin A, zinc and visual function in children with moderate to severe persistent asthma. Journal of Asthma. 2019 November; 56(11):1198-1203. doi:10.1080/02770903.2018.1531992. PMID:30380955.
  • Henry M, Chaku M, Gaynes BI, Barnes RJ. Surgical Outcomes in Combined iStent and Phacoemulsification in African American and White Glaucoma Patients. ARVO abstract#3148616, ARVO Annual Meeting, Vancouver, CA, 2019.
  • Duong S, Zaffer A, Yousefzai R, Chazaro Cortes J, Dieter R, Bahn G, Young J, Gaynes BI. Conjuctival Microvascular Hemorheologic Metrics as Biomarkers for Cardiovascular Disease. Loyola University Chicago, Stritch School of Medicine, St. Albert's Day October 24th, Maywood, IL 2019.
  • Henry M, Chaku M, Stefaniak A, Gaynes BI. The Effect of Phacoemulsification on Intraocular Pressure in African American Versus Caucasian Patients with Primary Open Angle Glaucoma. Loyola University Chicago, St. Albert's Day October 24th, Maywood, IL 2019.

2018

  • Gambino F, Liu H, Walsh C, Bouchard CS, Bu P, Gaynes BI, Qiao L. Anti-Inflammatory Action of a Novel Tetrapeptide in a Corneal Epithelial Cell Culture Model. ARVO abstract#C0050, ARVO Annual Meeting, Honolulu, HI, 2018.
  • Chazaro JM, Gaynes BI. Ocular Microcirculatory Metrics in Cardiovascular Disease. Loyola University Chicago, Stritch School of Medicine, St. Albert’s Day Symposium, November 8th, Maywood, IL 2018.

2017

  • Ethington J, Goldmeier D, Gaynes BI. Exponential Decay Metrics of Topical Tetracaine Hydrochloride Administration Describe Corneal Anesthesia Properties Mechanistically. Cornea. 2017;36:363-366. PMID:26154395.
  • Hunt S, Gaynes BI, Chaku M. The impact of cataract surgery in patients with low-tension glaucoma in a University setting. Posterboard #:B0412, Abstract Number:5315–B0412; ARVO Annual Meeting, Baltimore, MD, May 2017.
  • Sabherwal N, Kovach S, Nelligan M, Gaynes BI. Putative biomolecular pathways of retinal pigmented epithelial cytochrome c oxidase rescue by 670nm red light as outlined in a virtual study environment. Posterboard#:B0133; Abstract Number:5246-B0133, ARVO Annual Meeting, Baltimore, MD, May 2017.

2015

  • Kord VA, Wanek J, Saraf SL, Gaynes BI, Gordeuk VR, Molokie RE, Shahidi M. Changes in Conjunctival Hemodynamics Predict Albuminuria in Sickle Cell Nephropathy. American Journal of Nephrology. 2015;41:487-493.
  • Gaynes BI, Wanek J, Camardo N, Vicki G, Kansal M, Gans C, Shahidi M. Relationship between bulbar conjunctival hemorheology and metrics of cardiac function in patients with heart failure. Invest Ophthalmol Vis Sci. 2015;56(7):1972.
  • Burke L, Schmeling M, Tidow-Kebritchi S, Filip P, Elliot N, Gaynes J, Gaynes BI. In situ heavy metal concentrations in human aqueous humor and lens. Invest Ophthalmol Vis Sci. 2015;56(7):5719.

2014

  • Gaynes BI. Statins and cataract (letter). JAMA Ophthalmology. 2014;132:362-363.
  • Gaynes BI. Efficient bottle adaptation provides for adjustment of ophthalmic drop volume and drug dosage. Clinical and Experimental Ophthalmology. DOI:10.1111/ceo.12312. Published online:8 April 2014.
  • Schmeling M, Gaynes BI, Tidow-Krebitchi S. Heavy metal analysis in lens and aqueous humor of cataract patients by total reflection X-ray fluorescence spectrometry. Powder Diffraction. DOI:10.1017/S0885715614000281. Published online:24 April 2014.
  • Valeshabad AK, Wanek J, Zelkha R, Lim JI, Camardo N, Gaynes BI, Shahidi M. Conjunctival Microvascular Hemodynamics in Sickle Cell Retinopathy. Investigative Ophthalmology and Visual Science. 2014;55: E-Abstract 1465.
  • Gaynes BI, Spektor T, Nikolic N. Hospitalization rate among chronically ill low vision patients using a home prescription label reader vs. a pill box. Investigative Ophthalmology and Visual Science. 2014;55: E-Abstract 4160.
  • Iqbal O, Ottman A, Gaynes J, De Alba F, Gaynes BI, Fareed J, Bouchard CS. The Effects of Aspirin and its Metabolites on Peripheral Blood Mononuclear cells and Human Retinal Pigment Epithelial Cells - Implications in the Pathophysiology of Age-Related Macular Degeneration. Investigative Ophthalmology and Visual Science. 2014;55:E-Abstract 634.
  • Gaynes BI, Spektor T, Nikolic N. Hospitalization rate among chronically ill low vision patients using a home prescription label reader vs. a pill box. ARVO Annual Meeting, Orlando, FL, 2014. Abstract #4160 - A0148.
  • Iqbal O, Ottman A, Gaynes J, De Alba F, Gaynes BI, Fareed J, Bouchard CS. The Effects of Aspirin and its Metabolites on Peripheral Blood Mononuclear cells and Human Retinal Pigment Epithelial Cells - Implications in the Pathophysiology of Age-Related Macular Degeneration. ARVO Abstract #634 - B0161, Orlando, FL, 2014.
  • Iqbal O, Ottman A, Gaynes J, De Alba F, Gaynes BI, Fareed J, Bouchard CS. The effects of aspirin and its metabolites on peripheral blood mononuclear cells and human retinal pigment epithelial cells – implications in the pathophysiology of age-related macular degeneration. ARVO Annual Meeting, Orlando, FL, 2014. Abstract #634 - B0161.