Ph.D. 2005, Case Western Reserve University
The primary focus of my research is to understand the neurophysiological mechanisms of neurological diseases in the central nervous system (CNS), by using various types of in vitro and in vivo animal models. The primary research tools for this lab include electrophysiology (patch clamp), morphology, molecular biology, computer simulation, and neural engineering.
The functionality of the CNS is dependent on normal synaptic transmissions. Extracellular accumulation of an excitatory neurotransmitter, glutamate, is believed to be an important mediator of hypoxic/ischemic injury in the CNS. The disrupted balance between the excitatory glutamatergic and the inhibitory GABAergic transmission can cause neurons to transit from their quiescent state to a hyper-excitable state, a fundamental neurobiological basis for epilepsy. This research project aims to determine the underlying mechanisms that disrupt normal synaptic transmissions and to prevent these disturbances from occurring.
Approximately 280,000 people in North America currently suffer from SCI, a significant cause for morbidity and mortality. This research will focus on the neurophysiology bases of SCI and its novel treatment strategies, such as searching for new pharmacological targets, controlling neuron activity with electric current stimulation, and cell therapy with stem cell transplantation.
El-Hayek YH, Wu C, Ye H, Wang J, Carlen PL, Zhang L (2013) Hippocampal excitability is increased in aged mice. Experimental neurology. (in press)
Zhang ZJ, Koifman J, Shin DS, Ye H, Florez CM, Zhang L, Valiante TA, Carlen PL (2012) Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region. The Journal of neuroscience : the official journal of the Society for Neuroscience 32:2499-2512.
Ye H, Buttigieg J, Wan YD, Wang J, Figley S, Fehlings MG (2012) Expression and functional role of BK channels in chronically injured spinal cord white matter. Neurobiol Dis 47:225-236.
Ye H, Cotic M, Fehlings MG, Carlen PL (2011) Transmembrane potential generated by a magnetically induced transverse electric field in a cylindrical axonal model. Med Biol Eng Comput 49:107-119.
Ye H, Cotic M, Kang EE, Fehlings MG, Carlen PL (2010) Transmembrane potential induced on the internal organelle by a time-varying magnetic field: a model study. Journal of neuroengineering and rehabilitation 7:12.
Ye H, Jalini S, Mylvaganam S, Carlen P (2010) Activation of large-conductance Ca2+-activated K+ channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe/ind) TgCRND8 mice. Neurobiol Aging 31:591-604.
Ye H, Jalini S, Zhang L, Charlton M, Carlen PL (2010) Early ischemia enhances action potential-dependent, spontaneous glutamatergic responses in CA1 neurons. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 30:555-565.
Ye H, Cotic M, Carlen PL (2007) Transmembrane potential induced in a spherical cell model under low-frequency magnetic stimulation. Journal of neural engineering 4:283-293.
Ye H, Morton DW, Chiel HJ (2006) Neuromechanics of coordination during swallowing in Aplysia californica. The Journal of neuroscience : the official journal of the Society for Neuroscience 26:1470-1485.
Ye H, Morton DW, Chiel HJ (2006) Neuromechanics of multifunctionality during rejection in Aplysia californica. The Journal of neuroscience : the official journal of the Society for Neuroscience 26:10743-10755.