Ph.D. 2005, Case Western Reserve University
The primary focus of my research is to understand the neurophysiological mechanisms of neurological diseases in the central nervous system (CNS), by using various types of in vitro and in vivo animal models. The primary research tools include electrophysiology (field recording and whole cell patch clamp), pharmacology, and computer simulation. Our recent projects have focused on investing the possibility of using time-varying magnetic fields to control neural activity in epilepsy.
REPRESENTATIVE PUBLICATIONS (*undergraduate students)
Ye H, *Ng J, Shielding effects of myelin sheath on axolemma depolarization under transverse electric field stimulation. PeerJ. 2018 Dec 3;6:e6020.
Ye H, Mechanic stress generated by a time-varying electromagnetic field on bone surface. Medical & Biological Engineering & Computing. Med Biol Eng Comput. 2018 Oct;56(10):1793-1805.
Ye H, *Kaszuba S, Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis. J Biomed Sci. 2017 Dec 5;24(1):93.
Yang J, Zhang X, Zhu Y, *Lenczowski E, Tian Y, Yang J, Zhang C, Hardt M, Qiao C, Tanzi RE, Moore A, Ye H, Ran C. A double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chemical Science. 8, 6155-6164, 2017.
Ye H. Kinematic difference between a biological cell and an artificial vesicle in a strong DC electric field – a “shell” membrane model study. BMC Biophysics, 10:6, 2017.
Ye H, *Curcuru A. Deformation but not migration and rotation – a model study on vesicle biomechanics in a uniform DC electric field. Journal of Biomedical Engineering and Informatics. 2017; 3(1):18-27.
Ye H, *Curcuru A. Biomechanics of cell membrane under low-frequency time-varying magnetic field: a shell model. Medical & biological engineering & computing. 2016; 54(12):1871-1881.
*Finnegan J, Ye H. Cell therapy for spinal cord injury informed by electromagnetic waves. Regenerative medicine. 2016; 11(7):675-91.
Jalini S, Ye H, Tonkikh AA, Charlton MP, Carlen PL. Raised Intracellular Calcium Contributes to Ischemia-Induced Depression of Evoked Synaptic Transmission. PloS one. 2016; 11(3):e0148110.
Ye H, Steiger A. Neuron matters: electric activation of neuronal tissue is dependent on the interaction between the neuron and the electric field. Journal of neuroengineering and rehabilitation. 2015; 12:65.
Zhao H, Steiger A, *Nohner M, Ye H. Specific Intensity Direct Current (DC) Electric Field Improves Neural Stem Cell Migration and Enhances Differentiation towards βIII-Tubulin+ Neurons. PloS one. 2015; 10(6):e0129625.
Ye H, *Curcuru A. Vesicle biomechanics in a time-varying magnetic field. BMC biophysics. 2015; 8(1):2.
Liu Y, Ye H, Satkunendrarajah K, *Yao GS, Bayon Y, Fehlings MG. A self-assembling peptide reduces glial scarring, attenuates post-traumatic inflammation and promotes neurological recovery following spinal cord injury. Acta biomaterialia. 2013; 9(9):8075-88.
El-Hayek YH, Wu C, Ye H, Wang J, Carlen PL, Zhang L. Hippocampal excitability is increased in aged mice. Experimental neurology. 2013; 247:710-9.
&Ruff CA, &Ye H, *Legasto JM, Stribbell NA, Wang J, Zhang L, Fehlings MG. Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and enhancing performance. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2013; 33(29):11899-915. (& Contribute equally)
Ye H, Buttigieg J, Wan Y, Wang J, Figley S, Fehlings MG. Expression and functional role of BK channels in chronically injured spinal cord white matter. Neurobiology of disease. 2012; 47(2):225-36.
Zhang ZJ, Koifman J, Shin DS, Ye H, Florez CM, Zhang L, *Valiante TA, Carlen PL. Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2012; 32(7):2499-512.
Chen Z, Ye H, Xu H, An S, Jin A, Zhou C, Yang S. Rotating magnets produce a prompt analgesia effect in rats. Progress In Electromagnetics Research M. 2012; 27:203-217.
Ye H, Cotic M, Fehlings MG, Carlen PL. INFLUENCE OF CELLULAR PROPERTIES ON THE ELECTRIC FIELD DISTRIBUTION AROUND A SINGLE CELL Progress in electromagnetics research B. Pier B. 2012; 39:141-161.
Ye H, Cotic M, Fehlings MG, Carlen PL. Transmembrane potential generated by a magnetically induced transverse electric field in a cylindrical axonal model. Medical & biological engineering & computing. 2011; 49(1):107-19.
Ye H, Jalini S, Mylvaganam S, Carlen P. Activation of large-conductance Ca(2+)-activated K(+) channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe/ind) TgCRND8 mice. Neurobiology of aging. 2010; 31(4):591-604.
Ye H, Jalini S, Zhang L, Charlton M, Carlen PL. Early ischemia enhances action potential-dependent, spontaneous glutamatergic responses in CA1 neurons. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism. 2010; 30(3):555-65.
Ye H, Cotic M, Kang EE, Fehlings MG, Carlen PL. Transmembrane potential induced on the internal organelle by a time-varying magnetic field: a model study. Journal of neuroengineering and rehabilitation. 2010; 7:12.
Ye H, Cotic M, Carlen PL. Transmembrane potential induced in a spherical cell model under low-frequency magnetic stimulation. Journal of neural engineering. 2007; 4(3):283-93.
Ye H, Morton DW, Chiel HJ. Neuromechanics of multifunctionality during rejection in Aplysia californica. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2006; 26(42):10743-55.
Ye H, Morton DW, Chiel HJ. Neuromechanics of coordination during swallowing in Aplysia californica. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2006; 26(5):1470-85.